Welcome to the NORD Physician Guide to the Lipodystrophy Disorders. Information in this guide is provided by a clinician with expertise on this topic. This information is provided in the hope that it will help patients obtain timely diagnosis and treatment.
Lipodystrophies are disorders characterized by selective loss of adipose tissue (body fat) from various regions of the body. These disorders may be either inherited or acquired.
The author and NORD appreciate your interest in this topic. There are opportunities for follow-up questions and/or discussion in the Clinician Comments section of this guide.
The extent of fat loss can range from very small areas on one part of the body to near total absence of adipose from the entire body.
Lipodystrophies should be suspected in differential diagnosis of lean or non-obese patients presenting with early diabetes, severe hypertriglyceridemia, hepatic steatosis, hepatosplenomegaly, acanthosis nigricans, and polycystic ovarian syndrome.
Proper counseling of parents is critical for preventing unwanted stress and psychological sequelae in children affected by lipodystrophy.
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